Lonnie Ali began her business career with Kraft Foods, Inc. She continued her studies at UCLA’s Graduate School of Management and received an MBA in 1986. 

After her marriage to Muhammad Ali in November 1986, she assumed responsibility and management of his business affairs. In 1992, she formally incorporated Greatest of All Time, Inc. (GOAT Inc.) to centralize and license her husband’s intellectual properties for commercial purposes. She served as Vice President and Treasurer of GOAT, Inc. until the sale of the company in 2006. During her tenure, Lonnie managed the company’s daily operations and accompanied Muhammad on business trips and humanitarian initiatives, domestically and around the world. After the sale of GOAT, Lonnie was asked to serve on the management board of the newly formed Muhammad Ali Enterprises.

In 1997, Lonnie and Muhammad helped launch the Muhammad Ali Parkinson’s Center (MAPC) in Phoenix. Lonnie and her husband unveiled the Muhammad and Lonnie Ali Pavilion in 2009, which houses the Muhammad Ali Parkinson’s Center at Barrow Neurological Institute.

She and her husband opened the Muhammad Ali Center in Louisville in November of 2005, where she serves as a Lifetime Director and as Vice Chair of the Center’s Board.